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1996-02-27
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Document 0268
DOCN M9630268
TI TCR gamma/delta + and CD8+TCR alpha/beta + intraepithelial lymphocytes
(IEL) express proliferation marker (Ki-67) in the coeliac lesion.
DT 9603
AU Halstensen TS; Brandtzaeg P; Laboratory for Immunohistochemistry and
Immunopathology (LIIPAT),; National Hospital, University of Oslo,
Norway.
SO Adv Exp Med Biol. 1995;371B:1333-8. Unique Identifier : AIDSLINE
MED/96001750
AB In conclusion, it appears that gluten induces a non-proliferative
activation of CD4+ lamina propria T cells, but a proliferative
activation in the TCR alpha/beta +CD8+ and TCR gamma/delta + IEL
subsets. Although the increased density of TCR alpha/beta +CD8+ and TCR
gamma/delta + IEL in the coeliac lesion may be secondary to T cell
mediated immune activation in the lamina propria, a direct and primary
antigen-driven proliferation of IEL (perhaps CD1-dependent29) cannot be
excluded.
DE Adolescence Adult Aged Antigens, CD8/METABOLISM Biological Markers
Celiac Disease/*IMMUNOLOGY/PATHOLOGY Cell Division Child Child,
Preschool CD8-Positive T-Lymphocytes/IMMUNOLOGY/PATHOLOGY Human
Immunity, Mucosal Infant Intestinal Mucosa/*IMMUNOLOGY/PATHOLOGY
Jejunum/IMMUNOLOGY/PATHOLOGY Middle Age Neoplasm Proteins/*METABOLISM
Nuclear Proteins/*METABOLISM Receptors, Antigen, T-Cell,
alpha-beta/METABOLISM Receptors, Antigen, T-Cell,
gamma-delta/METABOLISM Receptors, Interleukin-2/METABOLISM
T-Lymphocyte Subsets/*IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).